Dee Velazquez

Software Developer @ JHU

As a research software developer, I tackle exciting challenges in computational biology and bioinformatics. I primarily work analyzing spatial transcriptomics, single-cell, and imaging data. My interests lie in developing interpretable, open-source machine learning, statistical, and computational software that empowers researchers to uncover meaningful insights from large-scale, high-dimensinsional biological & biomedical data, ultimately contributing to a deeper understanding of disease, development, and human health. I'm committed to creating user-friendly and accessible tools with strong data visualization principles and plan to pursue a Ph.D. to advance novel methodologies for the broader scientific community.

Featured Projects

A showcase of my work in machine learning, deep learning, computer vision, computational biology, full-stack development, and software development

Spatial Transcriptomics as Rasterized Image Tensors (STARIT)

An R and Python pipeline that converts imaging-based spatially resolved transcriptomics (im-SRT) data into image-based tensor representations to be used with feature extractors (ResNet101) for further downstream analysis in the identifcation and characteriztion of novel cell types & states by capturing subtle subcellular RNA heterogeneity that traditional gene count methods often miss.

scatterbar: Proportional Data Visualization in R

An R package designed for visualizing proportional data across spatial coordinates through scattered stacked bar plots. Built with ggplot2, dplyr, and tidyr, offering customizable visualizations for spatial data analysis and published on GitHub/CRAN.

COVID-19 Outcome Prediction Model

A machine learning model built using PyTorch to predict COVID-19 hospitalization and ICU admissions based on CDC surveillance data. Achieved a 94.4% PR AUC score with a Random Forest classifier through hyperparameter optimization and 3-fold cross-validation.

Fatigue Detection System for Road Safety

A real-time drowsiness detection system using OpenCV, Mediapipe, and dlib for facial landmark recognition. Analyzes Eye Aspect Ratio (EAR) and Mouth Aspect Ratio (MAR) to classify driver states, achieving 70.23% accuracy.

OncoBot: AI-Powered Cancer Education Chatbot

A full-stack chatbot developed to provide accessible cancer education to patients and families. Built with HTML, CSS, JavaScript, and React, featuring dynamic chatboxes, response delay handling, and accessibility improvements.

Exploring Supermasks with Genetic Algorithms

A collaboration with Universidad de Madrid exploring the Lottery Ticket Hypothesis through genetic algorithm development for optimizing supermasks in convolutional neural networks, achieving 8.5% performance improvements over random guessing.

Publications

Research contributions in computational biology and bioinformatics

3
Total Publications
1
Published
2
Preprint
2025
Latest Year
Published First Author

scatterbar: an R package for visualizing proportional data across spatially resolved coordinates

Bioinformatics (Oxford Academic)
2025
Volume 41, Issue 2
Dee Velazquez, Jean Fan†
†Corresponding author
An R package designed for visualizing proportional data across spatial coordinates through scattered stacked bar plots. Built with ggplot2, dplyr, and tidyr, offering customizable visualizations for spatial data analysis and computational biology research.
Preprint First Author

Spatial Transcriptomics As Rasterized Image Tensors (STARIT) characterizes cell states with subcellular molecular heterogeneity

bioRxiv
2025
DOI: 10.64898/2025.12.18.695193
Dee Velazquez, Caleb Hallinan, Roujin An, Kalen Clifton, Jean Fan†
†Corresponding author
A Python package that converts transcript coordinates from imaging-based spatially resolved transcriptomics into rasterized image tensors. By preserving subcellular spatial information, STARIT enables the use of computer vision models to identify cell types and states based on transcript localization patterns that conventional gene count methods overlook.
Preprint Co-Author

Spatiotemporal transcriptomic analysis of the murine kidney reveals compartment-specific changes during cold ischemic injury

bioRxiv
2025
DOI: 10.1101/2025.05.25.654911
Srujan Singh, Shishir Kumar Patel, Ryo Matsuura, Dee Velazquez, Zhaoli Sun, Sanjeev Noel, Hamid Rabb†, Jean Fan†
†Corresponding author
A comprehensive spatiotemporal analysis investigating transcriptomic changes in murine kidney tissue during cold ischemic injury, revealing compartment-specific molecular responses and providing insights into organ preservation strategies for transplantation.

Software

Open-source software projects and packages I have developed

scatterbar

An R package for visualizing proportional data across spatially resolved coordinates through scattered stacked bar plots.

Scatterbar Logo

Technical Expertise

Programming languages, packages, toolkits, software, and systems I work with and am proficient in

Programming Languages

Python R JavaScript Java C++ C Bash

Web Technologies

HTML5 CSS3 React Node.js

Data Science & ML

PyTorch OpenCV Pandas NumPy Matplotlib Seaborn Scikit-learn Plotly ggplot2 dplyr

Tools & Platforms

Git Windows Mac Linux Jupyter Notebooks RStudio

Resume

Download my full resume for detailed information about my experience and qualifications

Dee Velazquez - Resume

Software Developer & Post-Baccalaureate Researcher

PDF • Updated December 2025

Education

B.S. Computer Science & Chemical Engineering

Johns Hopkins University

Experience

Software Developer
JEFWorks Lab

Specialization

Computational Biology
Spatial Transcriptomics
Computer Vision
Deep Learning

Let's Connect

I'm always interested in discussing new opportunities and collaborations! (◕ っ ◕✿)